Author/Authors :
M?nica Gratac?s، نويسنده , , Marga Nadal، نويسنده , , Rocio Martin-Santos، نويسنده , , Miguel Angel Pujana، نويسنده , , Jordi Gago، نويسنده , , Belén Peral، نويسنده , , Llu??s Armengol، نويسنده , , Immaculada Ponsa، نويسنده , , Rosa Mir?، نويسنده , , Antoni Bulbena، نويسنده , , Xavier Estivill، نويسنده ,
Abstract :
Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.
