Author/Authors :
Kenji Matsushita ، نويسنده , , Craig N. Morrell، نويسنده , , Beatrice Cambien، نويسنده , , Shui-Xiang Yang، نويسنده , , Munekazu Yamakuchi، نويسنده , , Clare Bao، نويسنده , , Makoto R. Hara، نويسنده , , Richard A. Quick، نويسنده , , Wangsen Cao، نويسنده , , Brian OʹRourke، نويسنده , , John M. Lowenstein، نويسنده , , Jonathan Pevsner، نويسنده , , Denisa D. Wagner، نويسنده , , Charles J. Lowenstein، نويسنده ,
Abstract :
Nitric oxide (NO) inhibits vascular inflammation, but the molecular basis for its anti-inflammatory properties is unknown. We show that NO inhibits exocytosis of Weibel-Palade bodies, endothelial granules that mediate vascular inflammation and thrombosis, by regulating the activity of N-ethylmaleimide-sensitive factor (NSF). NO inhibits NSF disassembly of soluble NSF attachment protein receptor (SNARE) complexes by nitrosylating critical cysteine residues of NSF. NO may regulate exocytosis in a variety of physiological processes, including vascular inflammation, neurotransmission, thrombosis, and cytotoxic T lymphocyte cell killing.
