Title of article
HtrA2/Omi, a Sheep in Wolfʹs Clothing
Author/Authors
David L Vaux، نويسنده , , John Silke، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
251
To page
253
Abstract
Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.
Journal title
CELL
Serial Year
2003
Journal title
CELL
Record number
1018401
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