Author/Authors :
Bernd Schuettengruber، نويسنده , , Daniel Chourrout، نويسنده , , Michel Vervoort، نويسنده , , Benjamin Leblanc، نويسنده , , Giacomo Cavalli، نويسنده ,
Abstract :
Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins regulate the nuclear organization of their target genes and that PcG-mediated gene silencing involves noncoding RNAs and the RNAi machinery.
