Author/Authors :
Daniel P. Silver، نويسنده , , Stoil D. Dimitrov، نويسنده , , Jean Feunteun، نويسنده , , Rebecca Gelman، نويسنده , , Ronny Drapkin، نويسنده , , Shihua D. Lu، نويسنده , , Elena Shestakova، نويسنده , , Soundarapandian Velmurugan، نويسنده , , Nicholas DeNunzio، نويسنده , , Serban Dragomir، نويسنده , , Jessica Mar، نويسنده , , Xiaoling Liu، نويسنده , , Sven Rottenberg، نويسنده , , Jos Jonkers، نويسنده , , Shridar Ganesan، نويسنده , , David M. Livingston، نويسنده ,
Abstract :
BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (). (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
