Title of article :
Argonautes and Company: Sailing against the Wind
Author/Authors :
Suvendra N. Bhattacharyya، نويسنده , , Witold Filipowicz and Alexander Wlodawer، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
The 3′-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, report a new function for AGO2 and FXR1—two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3′-UTR of TNFα mRNA, unexpectedly activating its translation in a cell growth-dependent manner.
