Filling a GAP(DH) in Caspase-Independent Cell Death

Mitochondrial outer-membrane permeabilization can lead to cell death even without activation of caspases. In this issue of Cell, identify the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase as a potent inhibitor of caspase-independent cell death that may allow metabolically active cells to survive mitochondrial insult.