Author/Authors :
Wesley I. Sundquist، نويسنده , , Christopher P. Hill، نويسنده ,
Abstract :
Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.
