Title of article
The Yin and Yang of Treating BRCA-Deficient Tumors
Author/Authors
Richard W. Martin، نويسنده , , Philip P. Connell، نويسنده , , Douglas K. Bishop، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
2
From page
919
To page
920
Abstract
The myriad changes that occur during the malignant progression of cancer cells present challenges to both clinicians and basic scientists. Two new studies in Nature underscore the central role of genome instability in tumor biology (). These reports describe secondary changes in the BRCA2 locus that restore the wild-type reading frame and contribute to the development of resistance to chemotherapeutic agents.
Journal title
CELL
Serial Year
2008
Journal title
CELL
Record number
1019167
Link To Document