Abstract :
The microenvironment of a tumor is known to influence tumor progression and spread to distant sites (metastasis). now show that transient exposure of breast cancer cells to the signaling molecule transforming growth factor β (TGFβ) promotes their extravasation from blood vessels and entry into the lung by upregulation of the adipokine angiopoietin-like 4 (ANGPTL4). Their work shows that the later stages of metastasis can be influenced by transient signals produced in the primary tumor microenvironment.
