Interchromosomal Huddle Kickstarts Antiviral Defense

Long-distance chromosomal interactions are emerging as a potential mechanism of gene expression control. In this issue, describe how viral infection elicits interchromosomal associations between the interferon-β (IFN-β) gene enhancer and DNA binding sites of the transcription factor NF-κB, resulting in the initiation of transcription and an antiviral response.