Author/Authors :
Adriano Aguzzi، نويسنده , , Andrew D. Steele، نويسنده ,
Abstract :
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
