Title of article :
Caspases and Kinases in a Death Grip
Author/Authors :
Manabu Kurokawa، نويسنده , , Sally Kornbluth، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
17
From page :
838
To page :
854
Abstract :
The complex process of apoptosis is orchestrated by caspases, a family of cysteine proteases with unique substrate specificities. Accumulating evidence suggests that cell death pathways are finely tuned by multiple signaling events, including direct phosphorylation of caspases, whereas kinases are often substrates of active caspases. Importantly, caspase-mediated cleavage of kinases can terminate prosurvival signaling or generate proapoptotic peptide fragments that help to execute the death program and facilitate packaging of the dying cells. Here, we review caspases as kinase substrates and kinases as caspase substrates and discuss how the balance between cell survival and cell death can be shifted through crosstalk between these two enzyme families.
Journal title :
CELL
Serial Year :
2009
Journal title :
CELL
Record number :
1019915
Link To Document :
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