Author/Authors :
Minjia Tan، نويسنده , , Hao Luo، نويسنده , , Sangkyu Lee، نويسنده , , Fulai Jin، نويسنده , , Jeong Soo Yang، نويسنده , , Emilie Montellier، نويسنده , , Thierry Buchou، نويسنده , , Zhongyi Cheng، نويسنده , , Sophie Rousseaux، نويسنده , , Nisha Rajagopal، نويسنده , , Zhike Lu، نويسنده , , Zhen Ye، نويسنده , , Qin Zhu، نويسنده , , Joanna Wysocka-Diller، نويسنده , , Yang Ye، نويسنده , , Saadi Khochbin، نويسنده , , Bing Ren، نويسنده , , Yingming Zhao، نويسنده ,
Abstract :
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslational modification. The unique structure and genomic localization of histone Kcr suggest that it is mechanistically and functionally different from histone lysine acetylation (Kac). Specifically, in both human somatic and mouse male germ cell genomes, histone Kcr marks either active promoters or potential enhancers. In male germinal cells immediately following meiosis, Kcr is enriched on sex chromosomes and specifically marks testis-specific genes, including a significant proportion of X-linked genes that escape sex chromosome inactivation in haploid cells. These results therefore dramatically extend the repertoire of histone PTM sites and designate Kcr as a specific mark of active sex chromosome-linked genes in postmeiotic male germ cells.
