Title of article
Greasing the Path to BAX/BAK Activation
Author/Authors
Emilie Hollville، نويسنده , , Seamus J. Martin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
2
From page
845
To page
846
Abstract
BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.
Journal title
CELL
Serial Year
2012
Journal title
CELL
Record number
1021069
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