Hsp104 Gives Clients the Individual Attention They Need

Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms—individual subunits are able to dissolve disordered aggregates, but global subunit cooperativity is required to untangle amyloids.