Title of article :
A High-Resolution Enhancer Atlas of the Developing Telencephalon
Author/Authors :
Axel Visel، نويسنده , , Leila Taher، نويسنده , , Hani Girgis، نويسنده , , Dalit May، نويسنده , , Olga Golonzhka، نويسنده , , Renee V. Hoch، نويسنده , , Gabriel L. McKinsey، نويسنده , , Kartik Pattabiraman، نويسنده , , Shanni N. Silberberg، نويسنده , , Matthew J. Blow، نويسنده , , David V. Hansen، نويسنده , , Alex S. Nord، نويسنده , , Jennifer A. Akiyama، نويسنده , , Amy Holt، نويسنده , , Roya Hosseini، نويسنده , , Sengthavy Phouanenavong، نويسنده , , Ingrid Plajzer-Frick، نويسنده , , Malak Shoukry، نويسنده , , Veena Afzal، نويسنده , , Tommy Kaplan، نويسنده , , et al، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
14
From page :
895
To page :
908
Abstract :
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been identified, the distant-acting regulatory sequences orchestrating their in vivo expression are mostly unknown. Here, we describe a digital atlas of in vivo enhancers active in subregions of the developing telencephalon. We identified more than 4,600 candidate embryonic forebrain enhancers and studied the in vivo activity of 329 of these sequences in transgenic mouse embryos. We generated serial sets of histological brain sections for 145 reproducible forebrain enhancers, resulting in a publicly accessible web-based data collection comprising more than 32,000 sections. We also used epigenomic analysis of human and mouse cortex tissue to directly compare the genome-wide enhancer architecture in these species. These data provide a primary resource for investigating gene regulatory mechanisms of telencephalon development and enable studies of the role of distant-acting enhancers in neurodevelopmental disorders.
Journal title :
CELL
Serial Year :
2013
Journal title :
CELL
Record number :
1021588
Link To Document :
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