Title of article :
On Your MARK, Get SET(D2), Go! H3K36me3 Primes DNA Mismatch Repair
Author/Authors :
Christine K. Schmidt، نويسنده , , Stephen P. Jackson، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
