Carving Axon Arbors to Fit: Master Directs One Kinase at a Time

Pyramidal neurons in the cortex require the master kinase LKB1 for early axon specification. Courchet et al. now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.