Title of article :
Probing DNA by 2-OG-Dependent Dioxygenase
Author/Authors :
Chi-Lin Tsai، نويسنده , , Karl-Peter Hopfner and John A. Tainer، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Abstract :
TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.
