Determination of phenylephrine with a modified carbon paste electrode

An anodic stripping voltammetric method for determination of phenylephrine with a modified carbon paste electrode is developed. The modified carbon paste electrode was prepared with carbon paste mixed with a cation exchange resin containing the functional group CO2Na. Linear scan voltammetry was used for the electrochemical measurements. The experimental conditions for preconcentration and measurement steps have been optimized in order to attain the optimum analytical signal. In 0.1 M hydrochloric acid the drug shows a well defined oxidation peak at 1.07 V (vs. Ag/AgCl/3 M KC1). A procedure for determining phenylephrine in urine is also described.