Title of article
Fanconi Anemia (Cross)linked to DNA Repair
Author/Authors
Niedernhofer، Laura J. نويسنده , , Lalai، Astrid S. نويسنده , , Hoeijmakers، Jan H.J. نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
-1190
From page
1191
To page
0
Abstract
Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.
Keywords
IPM , DIGLYPHUS ISAEA , Liriomyza trifolii , Abamectin compatibility , Biological control , Greenhouse
Journal title
CELL
Serial Year
2005
Journal title
CELL
Record number
102364
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