• Title of article

    p120-Catenin Mediates Inflammatory Responses in the Skin

  • Author/Authors

    Perez-Moreno، Mirna نويسنده , , Davis، Michael A. نويسنده , , Wong، Ellen نويسنده , , Pasolli، H. Amalia نويسنده , , Reynolds، Albert B. نويسنده , , Fuchs، Elaine نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2006
  • Pages
    -630
  • From page
    631
  • To page
    0
  • Abstract
    Although p120-catenin regulates adherens junction (AJ) stability in cultured cells, genetic studies in lower eukaryotes have not revealed a role for this protein in vivo. Using conditional targeting in mice, we show that p120 null neonatal epidermis exhibits reduced intercellular AJ components but no overt disruption in barrier function or intercellular adhesion. As the mice age, however, they display epidermal hyperplasia and chronic inflammation, typified by hair degeneration and loss of body fat. Using skin engraftments and antiinflammatory drugs, we show that these features are not attributable to reductions in junctional cadherins and catenins, but rather NFkB activation. Both in vivo and in vitro, p120 null epidermal cells activate nuclear NFkB, triggering a cascade of proinflammatory NFkB targets. Although the underlying mechanism is likely complex, we show that p120 affects NFkB activation and immune homeostasis in part through regulation of Rho GTPases. These findings provide important new insights into p120 function.
  • Keywords
    Biological control , Abamectin compatibility , IPM , Greenhouse , Liriomyza trifolii , DIGLYPHUS ISAEA
  • Journal title
    CELL
  • Serial Year
    2006
  • Journal title
    CELL
  • Record number

    102416