Ionization constants of water insoluble arylpropionic acids in aqueous N,N-dimethylformamide mixtures from potentiometric pH-titrations

The ionization constants of five water insoluble anti-inflammatory arylpropionic acids were evaluated in 80% V/V N,N-dimethylformamide aqueous mixture. From these values, data on proton dissociation constants in water have been computed and compared with the results previously reported by using different approaches.