Electrochemical Determination of Antibacterial Drug Moxifloxacin Hydrochloride Using Chloranil Modified Carbon Paste Electrode

A highly sensitive electroanalytical method for the determination of moxifloxacin hydrochloride using differential pulse voltammetry was described. The electrochemical behavior of the used drug was investigated in Britton-Robinson buffer in the pH range of 2.0 to 11.0 at chloranil modified carbon paste electrode. The anodic peak currents increased linearly with the concentration in the range of 4.0×10-7 to 3.6×10-6 mol L-1. The limits of detection and quantification were 6.74×10-8 mol L-1 and 2.25×10-7 mol L-1, respectively. The relative standard deviation was found in the following range: 0.569-0.974%. The percentage recovery was found in the following range: 99.28-100.60%. The method was successfully applied to the determination of moxifloxacin hydrochloride in tablets without previous separation.