Author/Authors :
Manjunatha ، Jamballi G. نويسنده Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Karnataka, India , , Kumara Swamy، Bahaddurghatta E. نويسنده Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka 577451, India , , Shreenivas، Mellekatte Shreenivas T. نويسنده Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, Karnataka, India , , Mamatha ، Ganjeenahalli P. نويسنده Department of Pharmaceutical Chemistry, Kadur, Kuvempu University, Karnataka, India ,
Abstract :
A carbon paste electrode (CPE) modified with poly (nicotinic acid) was used for
the sensitive and selective voltammetric determination of dopamine (DA). The
electrochemical response characteristics of the modified electrode toward DA, ascorbic acid
(AA) were investigated by cyclic voltammetry (CV). The results show an efficient catalytic
activity of the electrode for the electro-oxidation of DA, which leads to an improvement to
the reversibility of the electrode response. The effect of pH and potential sweep rate on the
mechanism of the electrode process was investigated. The modified electrode exhibits an
efficient electron mediating behavior along with well-separated oxidation peaks for AA and
DA. Under the optimum pH of 7.0 in 0.2 M phosphate buffer solution (PBS), the CV anodic
peak current showed a linear relation vs. DA correlation coefficients. High sensitivity and
selectivity, high reproducibility, along with ease of preparation and regeneration of the
electrode surface by simple polishing make this method suitable for the determination of DA
and AA in pharmaceutical and clinical preparations.
