Author/Authors :
Islamnezhad، Akbar نويسنده Department of Chemistry, Faculty of Science, Islamic Azad University, Rasht Branch, Iran , , Mofidi، Jamshid نويسنده Department of Chemistry, Faculty of Science, Islamic Azad University, North Tehran Branch, Iran , , Madahi، Hamed نويسنده Department of Chemistry, Faculty of Science, Islamic Azad University, North Tehran Branch, Iran , , Mohammadi، Kamal نويسنده Research and development laboratory, Sobhandarou pharmaceutical company, Rasht, Iran ,
Abstract :
The electrochemical behavior of Galantamine (Gal) in aqueous media has been
examined by cyclic and differential pulse voltammetry. The voltammograms were
recorded with ?A utolab FRA2 Potentiostat-Galvanostat. A three-electrode system was
used with a glassy carbon as working electrode, a platinum rod as the counter electrode
and an Ag/AgCl as the reference electrode. All tests were carried out under room
temperature and N2 atmosphere. The pH strongly affects the peak potential of Gal. The
best analytical response was obtained at pH 2.0. The cathodic peak currents were
proportional to Gal concentrations in the range of 0.1–10 mM under the optimized
experimental conditions. The detection limit was 0.02 mM. The effect of potential scan
rate on the peak potential and peak current of Gal was investigated. The correlation of the
peak currents against v1/2 (v is the scan rate) is linear, which is very similar to a diffusioncontrolled
process. Proposed method applied to analysis of commercial tablets,
successfully.
