Author/Authors :
Nebsen، Marianne نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El-Aini 11562, Cairo, Egypt , , Elsayed، Ghada Mostafa نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo university, Kasr-El-Aini, 11562, Cair , Egypt , , Abdelkawy، Mohammed نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo university, Kasr-El-Aini, 11562, Cair , Egypt , , Elkhateeb، Sona Zaki نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo university, Kasr-El-Aini, 11562, Cair , Egypt ,
Abstract :
Three novel Xylometazoline Hydrochloride (XYLO) selective electrodes were
investigated with Dioctyl phthalate (DOP) as a plasticizer in a polymeric matrix of polyvinyl
chloride (PVC). Sensor 1 was fabricated using Phosphomolybdic acid (PMA) as an anionic
exchanger without incorporation of an ionophore. Sensor 2 used 2-hydroxy propyl ?-cyclodextrin
(hp?-CD) as an ionophore while sensor 3 was constructed using calix[6]arene as an ionophore.
Linear responses of XYLO within the concentration ranges of 10?4 to 10?2, 10?5 to 10?2 and 10?5 to
10?2 mol L?1 were obtained using sensors 1, 2 and 3, respectively. Nernstian slopes of 49.78, 56.21
and 46.20 mV/decade over the pH range of 5–9 for sensors 1, 2 and 5-7 for sensor 3 were
observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for
XYLO. The utility of 2-hydroxy propyl ?-cyclodextrin and calix[6]arene as ionophores had a
significant influence on increasing the membrane sensitivity and selectivity of sensors 2 and 3
compared to sensor 1. The proposed sensors displayed useful analytical characteristics for the
determination of XYLO in bulk powder, different pharmaceutical formulations, and biological
fluids (Rabbit aqueous humor) and in the presence of its degradation product (2, 6- dimethyl-4-tertbutyl-
phenylacetic acid) and thus could be used as stability-indicating method.
