Kinetic-Potentiometric Determination of Paracetamol and p-Aminophenol Using Partial Least Squares and Principal Components Regression Methods

Partial least squares (PLS) regression and principal component regression (PCR) multivariate calibration methods have been applied for the simultaneous determination of paracetamol (PAR) and p-aminophenol (PAP) using kinetic data obtained by novel potentiometric method. The method is based on the rate of chloride ion production in reaction of PAR and PAP with N-chlorosuccinimide (NCS) which is monitored by a chloride ion-selective electrode. The production rate of chloride ions in the reaction of PAR and PAP with NCS is different so that PLS and PCR can be applied to analyze the experimental potentiometric data. The determination of PAR and PAP is performed in the concentration ranges of 0.50-65.0 and 0.10-75.0 ?g mL-1, respectively. The total relative standard errors in PLS and PCR methods were calculated to be 4.07 and 4.74 for PAR and 3.93 and 4.79 for PAP, respectively