Surface-enhanced Raman detection of nicotinamide in vitamin tablets Original Research Article

Nicotinamide is analyzed quantitatively in vitamin tablets using surface-enhanced Raman scattering (SERS) on a silver-coated alumina substrate. Calibration curve of SERS signal intensity versus concentration of nicotinamide was established for quantitative analysis of this compound for detection at parts per million (ppm) level. SERS spectra of related compounds, nicotine, nicotinic acid, isonicotinic acid, and isonicotinamide were also recorded. Salient features of their spectra are compared and discussed.