Chiral separation of novel chiral tetrahedrone-type clusters on a cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase Original Research Article

Cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) coated on small particle silica gel was prepared. Direct enantiomeric resolution of six novel chiral tetrahedrone-type clusters has firstly been achieved on this CDMPC chiral stationary phase (CSP), using hexane as the mobile phase with various alcohols as modifiers. The influence of the mobile phase composition on the enantioselectivity was discussed, and the effect of structural variation of the solutes on their enantioseparation was also investigated and compared. It was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in tetrahedral core had significant effects on their chromatographic behaviors.