Capillary gas chromatographic properties of three new cyclodextrin derivatives with acyl groups in the 6-position of β-cyclodextrin Original Research Article

Three cyclodextrin derivatives (CDs) were synthesized by substituting different acyl groups (valeryl, heptanoyl, and octanoyl) in the 6-position of 2,3-di-O-pentyl-β-cyclodextrin. The chromatographic properties of the three CDs as capillary gas chromatographic stationary phases were investigated. It is found that the carbon chain length of acyl groups in the 6-position of the CDs has some effects on their enantioseparation abilities. Among the three cyclodextrin derivatives, 2,3-di-O-pentyl-6-O-valeryl-β-cyclodextrin possesses the best enantioselectivity to 15 pairs of enantiomers studied. The enantioseparation results are relate to both the structure of cyclodextrin derivatives and the structure of solutes.