Chemiluminescence determination of indapamide using indapamide-imprinted polymer as recognition material Original Research Article

A chemiluminescence reaction between soluble Mn(IV) and indapamide was found. An indapamide MIP was synthesized and its adsorption selectivity to indapamide in aqueous solution was evaluated. Using soluble Mn(IV)–formaldehyde–indapamide chemiluminesence system as detection system and the indapamide MIP as recognition material, a selective molecule imprinting-chemiluminesence method of determination of indapamide was established. The linearly response range of this method was from 2.0 × 10−8 to 5.0 × 10−6 g/mL with a linear correlation coefficient of 0.995. The detection limit was 8 × 10−9 g/mL. The relative standard deviation for 5.0 × 10−7 g/mL of indapamide solution was 3.5% (n = 9).