Simple and rapid determination of the active metabolite of nabumetone in biological fluids by heavy atom-induced room temperature phosphorescence Original Research Article

A simple, selective and sensitive heavy atom induced-room temperature phosphorimetric method is described for the determination of 6-methoxynaphthylacetic acid, main metabolite of nabumetone, in biological fluid. The phosphorescence signals are a consequence of intermolecular protection when analytes are, exclusively, in presence of heavy atom salt and sodium sulfite as an scavenger to minimize room temperature phosphorescence quenching. This technique enables us to determine analytes in complex matrices without the need for a tedious prior separation process.