Title of article :
Multi-residue monitoring for the simultaneous determination of five nitrofurans (furazolidone, furaltadone, nitrofurazone, nitrofurantoine, nifursol) in poultry muscle tissue through the detection of their five major metabolites (AOZ, AMOZ, SEM, AHD, DNSA
Author/Authors :
Eric Verdon، نويسنده , , Pierrick Couedor، نويسنده , , Pascal Sanders Close preview | ، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
12
From page :
336
To page :
347
Abstract :
Following the ban of four nitrofurans in the mid-90s (furazolidone, furaltadone, nitrofurantoine, nitrofurazone), the nifursol, a veterinary drug from the nitrofuran class of antibacterials which has been used prophylactically as feed additive for treating turkeys against histomoniasis (blackhead disease) was also declared in Annex IV of the European Union Directive no. 90/2377/EC in 2002 according to the Regulation no. 1756/2002/EC. As for the four other nitrofurans, nifursol disappears from tissues within a few days after treatment of food-producing animals. But toxic metabolites are still present for longer periods (several weeks or even months). The major metabolite that can readily be monitored in the tissues following nifursol abuse is the 3,5-dinitro-salicylic acid hydrazine (DNSAH). This article displays some improvements and the revalidation of the analytical method by liquid chromatography coupled to electrospray tandem mass spectrometry (LC-esiMS/MS) already in use in our laboratory for monitoring nitrofuran metabolites but also including the nifursol metabolite at the confirmatory minimum required performance level (MRPL) of 1 μg kg−1. The validation is applied both to artificially and to naturally incurred turkey muscle.
Keywords :
LC–MS/MS , Nitrofuran metabolites , Furazolidone , Turkey muscle , Furaltadone , Nitrofurantoine , Nifursol , Nitrofurazone
Journal title :
Analytica Chimica Acta
Serial Year :
2007
Journal title :
Analytica Chimica Acta
Record number :
1035470
Link To Document :
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