scaffolds Eects of bioglass nanoparticles on bioactivity andmechanical property of poly(3-hydroxybutirate(

The development of composite scaold materials in bone tissue engineering is gaining appeal, as the benecial properties of two or more types of material can be compounded together to better respond to the mechanical and physiological demands of the host tissue. In this study, poly (3-hydroxybutyrate) was reinforced with a dierent weight ratio of nanobioglass (0, 2.5, 5, 7.5 and 10 wt%). The nanocomposite scaolds were successfully prepared by the salt leaching process with various volume fractions of porosities (70, 80 and 90 wt% of NaCl). The results of our studies showed a favorable interaction between polymer and bioglass nanoparticles, which improved interfaces and mechanical properties, especially in samples which were prepared with 70 wt% NaCl. The Youngʹs modulus of samples ranged from 7.23 MPa to 48.27 MPa, which were in the range of the Youngʹs modulus of cancellous bone. The analysis results of samples which were immersed in SBF showed that hydroxyapatite formed on the nanocomposite scaold surfaces, and they exhibited high bioactivity compared to the pure PHB scaolds. In this study, nanobioglass, as a reinforcement phase with low mass fraction, is shown to be more eective than micro-materials with high mass fraction