Author/Authors :
Tahbaz-lahafi، Behnoosh نويسنده Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Akbari، Mohammad Esmaeil نويسنده Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Amir-Rassouli، Houshang نويسنده Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , , Azargashb، Eznollah نويسنده , , Nafissi، Nahid نويسنده Shahid Beheshti University of Medical Sciences, Cancer Research Center, Tehran, Iran , , Jahani، Farida نويسنده Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
Abstract :
Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.
Methods: 30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.
Results: Mean GZMH value was lower in BC than healthy women (p < 0.0001).
Conclusions: our study has implicated suppressor existence, or the problem for producing of GZMH in patients group, and levels of estrogen that could not effect on making positive ER, PR.
Conclusion: Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn’t effect on making positive ER, PR.
