Author/Authors :
Ahmadi Abhari، Seyed Ali نويسنده Department of Psychiatry and Psychiatry Research Center, Tehran University of Medical Sciences , , Sadeghi Zadeh، Majid نويسنده , , Samimi Ardestani، Seyed Mehdi نويسنده Behavioral Sciences Research Center Shahid Beheshti University of Medical Sciences , , Mirsepassi، Gholamreza نويسنده Department of Psychiatry and Psychiatry Research Center, Tehran University of Medical Sciences , , Sadr، Seyed Saeed نويسنده Behavioral Sciences Research Center Shahid Beheshti University of Medical Sciences , , Kamaloo، Atefe نويسنده Department of Psychiatry and Psychiatry Research Center, Tehran University of Medical Sciences , , Ahadi، Morvarid نويسنده Department of Psychiatry and Psychiatry Research Center, Tehran University of Medical Sciences , , Pourmirza ، Behin نويسنده Sanofi Medical Departments , , Mir، Elham نويسنده Sanofi Medical Departments ,
Abstract :
Objective: Bipolar spectrum disorders may often go undiagnosed or unrecognized. The aim of this study was to determine the proportion of bipolar disorder symptoms in Iranian patients with a major depressive episode.
Methods: 313 patients with a current DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders 4th ed. Text rev.) diagnosed with a major depressive episode entered this cross-sectional study. Thirty two items revised Hypomania/ mania Symptoms Checklist (HCL-32) was used to determine the frequency of bipolar episodes.
Results: Considerable proportion of patients (53.9%) previously diagnosed as major depressive disorder fulfilled the criteria for bipolar disorder by Bipolarity Specifier. The Bipolarity Specifier additionally identified significant association for manic / hypomanic states during antidepressants therapy (p < 0.0003) and current mixed mood symptoms (p < 0.0001)
Conclusion: Bipolar symptoms meeting the criteria for bipolar disorders in depressed patients who have not been previously diagnosed with bipolar disorder are frequent. Current DSM criteria may not be sufficient to diagnose more subtle or atypical forms of bipolar disorders.
