Author/Authors :
Chang-Hai Wang، نويسنده , , Tzu-En Hua، نويسنده , , Chia-Chi Chien، نويسنده , , Yen-Lu Yu، نويسنده , , Tsung-Yeh Yang، نويسنده , , Chi-Jen Liu، نويسنده , , Wei-Hua Leng، نويسنده , , Y. Hwu، نويسنده , , Yung-Chin Yang، نويسنده , , Chong-Cook Kim، نويسنده , , Jung Ho Je، نويسنده , , Chih-Hsiung Chen، نويسنده , , Hong-Ming Lin، نويسنده , , G. Margaritondo، نويسنده ,
Abstract :
Reductant, stabilizer-free colloidal gold solutions were fabricated by a new room-temperature synchrotron X-ray irradiation method. The influence of process parameters such as the pH value and the exposure time on the structure of gold nanoparticles was investigated. The mechanisms underlying the X-ray-triggered reduction of gold ions and the formation of gold clusters are discussed in detail. The X-ray irradiation derived highly concentrated gold nanoparticles are readily to be re-dispersed and possess suitable colloidal stability within cellular environment. The characterization included a study of the possible cytotoxicity for the EMT-6 tumor cell line: the negative results indicate that the gold clusters produced with our approach are biocompatible.
