Author/Authors :
T.، Muller, نويسنده , , J.، Kentsch, نويسنده , , M.، Durr, نويسنده , , T.، Schnelle, نويسنده , , G.، Gradl, نويسنده , , M.، Jager, نويسنده , , A.، Normann, نويسنده , , M.، Stelzle, نويسنده ,
Abstract :
Microfabrication and performance of a novel microsystem for separation, accumulation and analysis of biological micro- and nanoparticles is reported. Versatile chip functions based on dielectrophoresis and microfluidics were integrated to isolate particles from complex sample solutions such as serum. A bead-based assay for virus detection is proposed. Separation of micro- and sub-(mu)m beads employing dielectrophoretic deflector and bandpass structures is demonstrated. Individual antibody coated beads with hepatitis A virus bound to their surface were trapped by negative dielectrophoresis in a field cage and analysed by fluorescence microscopy.
