Title of article
Synthesis of Homoprotoberberines and 8-Oxoprotoberberines by Sequential Bicyclization of Phenylacetamides
Author/Authors
Rafael Suau، نويسنده , , Juan Manuel Lopez-Romero، نويسنده , , Antonio Ruiz، نويسنده , , Rodrigo Rico، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
993
To page
998
Abstract
The reaction of phenylacetamides with oxalyl chloride/Lewis acid provides a convergent, high-yield entry to C-homoprotoberberine and 8-oxoprotoberberine alkaloids from available starting materials. This approach was used to synthesize 8-oxopseudopalmatine starting from N-[β-(3′,4′-dimethoxyphenyl)ethyl]-3,4-dimethoxyphenylacetamide. Some C-homoprotoberberines exhibit significant cytotoxicity against human breast carcinoma cells.
Keywords
oxalyl chloride , homoprotoberberines , Phenylacetamides , Alkaloids , isoquinolines , Cytotoxicity
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080571
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