Facile One-pot Synthesis of Macrobicyclic/Macrotricyclic Cryptands: Effect of Reactant Concentrations

Under high concentration conditions, tripodal trialdehyde 1 undergoes [2+3] Schiff base condensation with linear aliphatic diamines at room temperature to form macrobicyclic cryptands while two tripodal trialdehydes 1 or 2 undergo [2+2] Schiff base condensation with two tripodal triamines to form macrotricylic cryptands. Another macrotricyclic cryptand is formed via [4+6] amidation reaction.