A Practical Stereoselective Synthesis of both Enantiomers of Threo- and Erythro-β-Hydroxy Norvaline from (S)-Serine Derivatives

The four enantiopure diastereoisomers of β-hydroxy norvaline have been prepared from l-serine in moderate chemical yield. The method is based on the diastereoselective addition of different organometallics to easily accessible serinal derivatives.