Title of article
Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their use for the Synthesis of Fluoroquinolones
Author/Authors
Alexander Ya. Aizikovich، نويسنده , , Maxim V. Nikonov، نويسنده , , Michael I. Kodess، نويسنده , , Vladislav Yu. Korotayev، نويسنده , , Valery N. Charushin، نويسنده , , Oleg N. Chupakhin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
1923
To page
1927
Abstract
A common approach to the synthesis of 1-trifluoromethyl-1,2-ethylenediamines was developed. Based on these original building blocks the new derivatives of N-substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7JF–F between the trifluoromethyl group and F-8 were measured in the 19F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19F{19F} double resonance technique.
Keywords
2-ethylenediamines , trifluoromethyl group , 1-trifluoromethyl-1 , Fluoroquinolones
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080674
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