Novel 1-Trifluoromethyl Substituted 1,2-Ethylenediamines and Their use for the Synthesis of Fluoroquinolones

A common approach to the synthesis of 1-trifluoromethyl-1,2-ethylenediamines was developed. Based on these original building blocks the new derivatives of N-substituted fluoroquinolones bearing the trifluoromethyl group were obtained. Through-space transmitted coupling constants 7JF–F between the trifluoromethyl group and F-8 were measured in the 19F NMR spectra of all fluoroquinolones examined and assigned unequivocally by using 19F{19F} double resonance technique.