Author/Authors :
Naoko Morisaki، نويسنده , , Koji Morita، نويسنده , , Asuka Nishikawa، نويسنده , , Noriyuki Nakatsu، نويسنده , , Yasuhisa Fukui، نويسنده , , Yuichi Hashimoto، نويسنده , , Ryuichi Shirai، نويسنده ,
Abstract :
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated under the same condition. The chirality of sn-2 center was not responsible for the phosphorylation reaction.
Keywords :
Phosphoric acids and derivatives , carboxylic acids and derivatives , Inositols , enzymes and enzyme reactions
