Title of article
Copper Hydride-Catalyzed Tandem 1,4-Reduction/Alkylation Reactions
Author/Authors
Bruce H. Lipshutz، نويسنده , , Will Chrisman، نويسنده , , Kevin Noson، نويسنده , , Patrick Papa، نويسنده , , Joseph A. Sclafani، نويسنده , , Randall W. Vivian، نويسنده , , John M. Keith، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
10
From page
2779
To page
2788
Abstract
Exposure of an enone to a catalytic quantity of [CuH(PPh3)]6 in the presence of one of several silyl hydrides (PhMe2SiH, PMHS, HMe2SiOSiMe2H) leads to conjugate reduction with concomitant formation of the corresponding silyl enol ether. Without isolation, treatment of these intermediates with a Lewis acid at low temperatures in the presence of an aldehyde, or with fluoride ion together with an activated halide, affords good yields of the product of 3-component coupling (3-CC) in a single reaction flask.
Keywords
conjugate reduction , silyl hydrides , copper hydride
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080759
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