Author/Authors :
Stan V. DʹAndrea، نويسنده , , Daniel Bonner، نويسنده , , Joanne J. Bronson، نويسنده , , Junius Clark، نويسنده , , Ken Denbleyker، نويسنده , , Joan Fung-Tomc، نويسنده , , Shelley E. Hoeft، نويسنده , , Thomas W. Hudyma، نويسنده , , John D. Matiskella، نويسنده , , Raymond F. Miller، نويسنده , , Peter F. Misco، نويسنده , , Michael Pucci، نويسنده , , Roman Sterzycki، نويسنده , , Yuan Tsai، نويسنده , , Yasutsuga Ueda، نويسنده , , John A.، نويسنده ,
Abstract :
Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropyrid-4-ylthioacetamido. The C-3 thiopyridinium rings were substituted at nitrogen with amino acid and pyruvic acid groups that were designed to confer aqueous solubility as required for IV formulation. This paper describes the characteristics of these novel cephalosporins and highlights synthetic methods developed to allow their practical, large-scale syntheses.
Keywords :
novel cephalosporins , 2 , 2 , 5-dichlorophenylthioacetamido , 6-dichloropyrid-4-ylthioacetamido , anti-MRSA activity
