Title of article
Reaction of Clavams with Elastase Reveals a General Method for Inhibiting ‘Serine’ Enzymes
Author/Authors
Rupert C. Wilmouth، نويسنده , , Yin-Hong Li، نويسنده , , Penny A. Wright، نويسنده , , Timothy D.W. Claridge، نويسنده , , Robin T. Aplin، نويسنده , , Andrea G. Prescott and Christopher J. Schofield، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
5729
To page
5733
Abstract
Ester derivatives of clavulanic acid acylate Ser-195 of the serine protease porcine pancreatic elastase to form stable malonyl semi-aldehyde derivatives, analogous to those formed in the inhibition of β-lactamases by clavulanic acid itself. Formation of such derivatives maybe a general way of inhibiting ‘serine’ enzymes.
Keywords
clavams , elastase , serine enzymes
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081068
Link To Document