Title of article :
Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol
Author/Authors :
S Chandrasekhar، نويسنده , , M Venkat Reddy، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.
Keywords :
Coupling reaction , Epoxidation , Amine , Antihypertensive , chromanes
Journal title :
Tetrahedron
Journal title :
Tetrahedron
