Adociasulfate 10, A New Merohexaprenoid Sulfate from the Sponge Haliclona (aka Adocia) sp.

The meroterpenoid adociasulfate 10 was isolated from the Palauan sponge Haliclona (aka Adocia) sp., together with the previously reported metabolites adociasulfates 1–6. Unlike other adociasulfates, which contain mono- or di-sulfated hydroquinones, adociasulfate 10 contains an unusual glycolic acid residue in place of one of the sulfate groups. Adociasulfate 10 is an inhibitor of the kinesin family of microtubule motor proteins with an IC50 of 7 μM.